New Tools for Oligonucleotide Fingerprinting
نویسندگان
چکیده
منابع مشابه
Oligonucleotide Aptamers: New Tools for Targeted Cancer Therapy
Aptamers are a class of small nucleic acid ligands that are composed of RNA or single-stranded DNA oligonucleotides and have high specificity and affinity for their targets. Similar to antibodies, aptamers interact with their targets by recognizing a specific three-dimensional structure and are thus termed "chemical antibodies." In contrast to protein antibodies, aptamers offer unique chemical ...
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Let s = s1 . . . sn be a text (or sequence) on a finite alphabet Σ. A fingerprint in s is the set of distinct characters contained in one of its substrings. Fingerprinting a text consists of computing the set F of all fingerprints of all its substrings and being able to efficiently answer several questions on this set. A given fingerprint f ∈ F is represented by a binary array, F , of size |Σ| ...
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We report on a genome-independent microbial fingerprinting method using nucleic acid microarrays for microbial forensics and epidemiology applications and demonstrate that the microarray method provides high resolution differentiation between closely related microorganisms, using Salmonella enterica strains as the test case. In replicate trials we used a simple 192 probe nonamer array to constr...
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Current bacterial DNA-typing methods are typically based on gel-based fingerprinting methods. As such, they access a limited complement of genetic information and many independent restriction enzymes or probes are required to achieve statistical rigor and confidence in the resulting pattern of DNA fragments. Furthermore, statistical comparison of gel-based fingerprints is complex and nonstandar...
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ژورنال
عنوان ژورنال: BioTechniques
سال: 2001
ISSN: 0736-6205,1940-9818
DOI: 10.2144/01313st01